Prepare the Gut: The Microbiome’s Role in Protein Absorption

Protein is often evaluated by the amount in each serving, its amino acid profile, or whether it comes from an animal or plant source. But before the body can use that protein, it must first be digested into smaller peptides and amino acids, absorbed through the small intestine, and released into circulation. For active individuals and those focused on healthy aging, the digestive environment is an important part of the protein story.¹

Essential amino acids are especially important because the body cannot produce them on its own. They must come from the diet, and their appearance in the bloodstream provides an indication of how effectively dietary protein has been digested and absorbed. Protein quality and quantity still matter, but so does the body’s ability to access the amino acids that protein provides.¹

The gut microbiome is part of that process. Microorganisms in the digestive tract interact with nutrients, contribute to metabolic activity, and help shape the environment where digestion and absorption occur. Emerging research suggests that select probiotics may support amino acid absorption when consumed with protein, bringing microbiome support into a category that has traditionally focused on the protein source alone.²

Preparing the gut for protein means supporting the environment where digestion and nutrient absorption take place. This concept was explored in a clinical study of Mycohsa™, a probiotic blend containing beneficial bacteria, yeast and the enzyme amylase. When Mycohsa was consumed alongside pea protein, plasma essential amino acid concentrations were 4.4% higher at 120 minutes than with pea protein alone. Researchers also observed changes across both bacterial and fungal communities in the gut.³

Rather than treating gut health and protein nutrition as separate conversations, these findings point to a connection between the two. A well-supported digestive environment may help the body break down protein and make its amino acids more available—an emerging area of interest for active nutrition and healthy aging.³

From a product development perspective, this creates an opportunity to think beyond simply adding more protein. Brands can also consider complementary products designed to support the digestive environment around protein intake.

Before protein can deliver its nutritional value, the body has to be able to use it. It’s a simple idea: prepare the gut, then power the protein.

References

  1. Goodman BE. Insights into digestion and absorption of major nutrients in humans. Adv Physiol Educ. 2010;34(2):44–53.
  2. Jager R et al. Probiotic Administration Increases Amino Acid Absorption from Plant Protein: a Placebo-Controlled, Randomized, Double-Blind, Multicenter, Crossover Study. Probiotics Antimicrob Proteins. 2020;12(4):1330–1339.
  3. Retuerto M et al. Probiotic supplementation of pea-derived protein alters the gut microbiome balance in favor of increased protein degradation, reflected in increased levels of essential amino acid in human plasma. Gastroenterol Hepatol Open Access. 2023;14(4):93–103.

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